Refine your search
Collections
Co-Authors
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Pandeya, S. N.
- Synthesis and Antitumour Activity of some Aryl Semicarbazones
Abstract Views :178 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005, IN
2 Division of Cancertreatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, US
1 Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005, IN
2 Division of Cancertreatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, US
Source
Scientia Pharmaceutica, Vol 68, No 4 (2000), Pagination: 369-377Abstract
Various 4-substituted phenyl semicarbazone derivatives were synthesized and evaluated in vitro by NCI in the 3-cell line, one dose primary anticancer assay. Three compounds showed significant activity against breast MCF7 cell line and were further evaluated for potential anticancer activity in an in vitro human disease-oriented tumour cell line screening panel that consisted of 60 human tumour cell lines arranged in nine subpanels, representing diverse histologies. Leukemia, colon, ovarian and breast cancer cell lines were relatively more sensitive to these compounds than the other cell lines. The 4-carboxy substituted p-nitrobenzylidene phenyl semicarbazone (lc) emerged as the most active compound with average GI50 value (the molar drug concentration required for the 50% growth inhibition) of 28.6(J.M. This compound showed greater activity than methotrexate against NCI-H226(Lung), BT-549 and T-47D(Breast) cancer cell lines.Keywords
Aryl semicarbazones, Antitumour, MethotrexateReferences
- Cotti L., (1940) Biochem. Terap. Sper. 27, 366; (1943) C.A. 37, 4421.
- Dimmock J. R., Baker G. B., (1994) Epilepsia 35(3), 645.
- Pandeya S. N., Aggarwal N., Jain J. S., (1009) Pharn~azie5 4, 300.
- Pandeya S. N., Mishra V., Singh P. N., Rupainwar D. C., (1998) Pharn~acolR. es. 37, 17.
- Fedorova 0. V., Mordovskoi G. G., Rusinov G. L.; Ovchinnikova I. G., Zueva M. N. Kravchenko M. A., Chupakhin 0. N., (1998) Khim.-Farm. Zh. 32(2), 1 I.
- Wang Y., Cai S. X., Lan N. C., Keena J. F. W., Illyin V. I., Weber E., WO 98 47,869 (1998) C. A. 26, P343416v.
- Schulze W., Jungstand W., Gutsche W., Wohlrabe K., Horn G., (1978) Pharmazie 33, 11 1.
- Fichtner J., Arnold W., (1983) Phannazie 38, 30.
- Dimmock J. R., Kirkpatrick D. L., Negrave L. E., Russel K. L., Pannekock W. J., (1991 ) Can. J. Pharm. Sci. 16, 1.
- Gugova R., Raikov Z., Zakhariev S., Demirov G., Todorov D., Harionova M., (1989) Drugs Exp. Clin. Res. 15,497.
- Schaffner K., Traxler P., Zimmermann M., Wehrli W., Scmidtappin K. H., EP 183649, (1 986) C. A. 105, 152929j.
- Vancurova J., Krepelka J., Rezabez K., Melka M., CS2 12670, ( 1 985) C. A. 102, P2037042.
- Brzozowski Z., (1998) Acta Pol. Pharm. 55(3), 233.
- Conti G. M., Gaozza C. H., (1996) Farmaco 5 1(6), 41 9.
- Rosowsky A., Wright J. E., Vaidya C. M., Bader H., Forsch R. A., Mota C. E., Pardo J., Chen C. S,, Chen Y. N., (1998) J. Med. Chem. 41,5310.
- Rosowsky A,, Papouli A.T., Forsch R. A., Queener S. F., (1 999) J. Med. Chem. 42, 1007.
- Boyd M. R., Paul1 K. D., (1 995) Drug Development Res. 3491.
- Synthesis and Antituberculous Activity of N-Mannich Bases of 3-[4-(4-Chlorophenyl)-6-(4-methylphenyl) Pyrimidin-2-yl] Iminoisatin Derivatives
Abstract Views :193 |
PDF Views:0
Authors
Affiliations
1 Medicinal Chemistry Research Laboratory, Pharmacy Group, Birla Institute of Technology and Sciences, Pilani, Rajasthan-333031, IN
2 Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005, IN
3 National Institute of Allergy and Infectious Diseases, TAACF, Southern Research Institute, 2000, 9th Avenue South, Birmingham, AL 35255, US
1 Medicinal Chemistry Research Laboratory, Pharmacy Group, Birla Institute of Technology and Sciences, Pilani, Rajasthan-333031, IN
2 Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005, IN
3 National Institute of Allergy and Infectious Diseases, TAACF, Southern Research Institute, 2000, 9th Avenue South, Birmingham, AL 35255, US
Source
Scientia Pharmaceutica, Vol 70, No 1 (2002), Pagination: 39-48Abstract
Isatin, its 5-chloro and 5-bromo derivatives have been reacted with 4-(4-chloropheny1)-6-(4-methylphenyl)-2-aminopyrimidine to form Schiff bases and the N-Mannich bases of these compounds were synthesized by reacting them with formaldehyde and several secondary amines. The compounds were evaluated in vitro against Mycobacterium tuberculosis 1137Rv at 6.25 μg/ml in BACTEC 12B medium using the BACTEC 460 radiometric system. Among the compounds tested 3-[4-(4-ch1orophenyl)-6-(4-methylphenyl) pyrimidin-2-yl]iminoisatin (S1) showed promising activity with 97% inhibition at a concentration of 6.25 μg/ml.Keywords
Isatin, Mannich Bases, Schiff Bases, Antituberculous.References
- Brudney K., Dobkin J., (1991) Am. Rev. Respir. Dis. 144, 745.
- Gangadharam P. R. J., (1988) Peterson P. K., Verhoef J., (Eds.) The Antimicrobial Agent Annual, 3rd edition, Elsevier, Amsterdam/Main, 15.
- Mandell G. L., Sande M. A., (1990) Gilman A. G., Goodmann L. S., Rall T. W., Nies A. S., Taylor P., (Eds.) The Pharmacological basis of Therapeutics, 8th edition Pergamon Press, New Yorkl Main, 1146.
- Pandeya S. N., Sriram D ., Yogeeswari P., Ananthan S., (2001) Chemotherapy 47, 266.
- Pandeya S. N., Sriram D., (1998) Acta Phann. Turc. 40, 33.
- Pandeya S. N., Sriram D., De Clercq E., Pannecouque C., Witvrouw M., (1998) Indian J. Pharm. Sci. 60, 207.
- Pandeya S. N., Yogeeswari P., Sriram D., Nath G., (1998) Boll. Chim. Farm. 137, 321.
- Pandeya S. N., Yogeeswari P., Sriram D., De Clercq E., Pannecouque C., Witvrouw M., (1999) Chemotherapy 45, 192.
- Pandeya S. N., Sriram D., Nath G., De Clercq E., (2000) Eur. J. Med. Chem. 35, 265.
- Pandeya S. N., Sriram D., Nath G., De Clercq E., (2000) Arzneim.-Forsch./Drug Res. 50(1), 55.
- Pandeya S. N., Sriram D., Nath G., De Clercq E., (1999) Sci. Phatm. 67, 103.
- Pandeya S. N., Sriram D., Nath G., De Clercq E., (1999) Pharm. Acta Helv. 74, 11.
- Inderleid C, B., Nash K. A., (1996) Lorian V., (Eds.) Antibiotics in Laboratory Medicine, 4th edition, Williams & Wilkins, Baltimore/Main, 127.
- Inderleid C. B., Salfinger M., (1995) Murray P. R., Baron E. J., Pfaller M. A., Tenover F. C., Yoken R. H., (Eds.) Manual of Clinical Microbiology, 6th edition, ASM Press, Washington/Main, 1385.
- Various Methods for Synthesis of Purine Analogues
Abstract Views :230 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Sciences, Saroj Institute of Technology and Management, Lucknow, IN
1 Department of Pharmaceutical Sciences, Saroj Institute of Technology and Management, Lucknow, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 9 (2011), Pagination: 1361-1365Abstract
The purine analogues are new class of nonclassical antimicrobial agents that binds with riboswitches. Purine (adenine) analogues are having antimicrobial, antifungal, antitumour, antiproliferative, antiviral and activity against HSV-1. Riboswitches are structured RNA domains that can bind directly to specific ligands and regulate gene expression. These RNA elements are located most commonly within the non-coding regions of bacterial mRNAs, because these genes were involved in fundamental metabolic pathways in certain bacterial pathogens. Purine-binding riboswitches may be targets for the development of novel antimicrobial agents. Designed compounds are bound by a purine riboswitches aptamer in vitro with affinities comparable to that of the natural ligand, and several also inhibit microbial growth.Keywords
Purines, Synthesis.- Various Approaches for Synthesis of 1, 5 -Benzodiazepines
Abstract Views :219 |
PDF Views:0
Authors
S. N. Pandeya
1,
Neha Rajput
1
Affiliations
1 Department of Pharmaceutical Sciences, Saroj Institute of Technology & Management, Sultanpur Road, Lucknow-226002 (U.P.), IN
1 Department of Pharmaceutical Sciences, Saroj Institute of Technology & Management, Sultanpur Road, Lucknow-226002 (U.P.), IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 6 (2011), Pagination: 863-872Abstract
Benzodiazepines and its derivatives constitute an important class of heterocyclic compounds which possess a wide range of therapeutic and pharmacological properties. This manuscript includes efficient synthesis of various derivatives of 1,5-benzodiazepines by different methods.Keywords
1,5-Benzodiazepines, Heterocyclic, Pharmacological Properties.- Chemistry of Fullerene and it’s Application:A Review
Abstract Views :198 |
PDF Views:0
Authors
Affiliations
1 Saroj Institute of Technology and Management, Lucknow, U.P., IN
2 Pranveer Singh Institute of Technology, Kanpur, U.P., IN
1 Saroj Institute of Technology and Management, Lucknow, U.P., IN
2 Pranveer Singh Institute of Technology, Kanpur, U.P., IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 234-242Abstract
The discovery of fullerenes has opened a new chapter on the physics and chemistry of carbon. So far, the physical and chemical properties of fullerenes are still under investigation. More research is needed to be done to confirm the suitability of some important application. Some potential applications will need more time for them to become reality. Their unique carbon cage structure coupled with immense scope for derivatization makes fullerenes a potential therapeutic agent. Henceforth chemistry and various potential therapeutic applications of fullerenes have been reviewed in the present paper. These include anti HIV-protease activity, photodynamic DNA cleavage, free radical scavenger, antimicrobial action and use of fullerenes as diagnostic agents.Keywords
Fullerenes, Anti-HIV Agent, Antibacterial Agent, DNA Photo Cleavage, Anti-Oxidant.- Synthesis and Biological Activity of N-(1-Alkyl-4-Phenyl-6-Thioxo-1, 6-Dihydro-1, 3, 5-Triazine-2-Yl)-N-Arylidine Hydrazine
Abstract Views :153 |
PDF Views:0
Authors
Affiliations
1 Saroj Institute of Tech. and Management, Lucknow-226002, IN
2 Harish Chandra P.G. College, Varanasi, IN
1 Saroj Institute of Tech. and Management, Lucknow-226002, IN
2 Harish Chandra P.G. College, Varanasi, IN